Dietary Fiber Intake and Head and Neck Cancer Risk: A Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

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Citation

Kawakita, Daisuke; Lee, Yuan-Chin Amy; Turati, Federica; Parpinel, Maria; Decarli, Adriano; Serraino, Diego; Matsuo, Keitaro; Olshan, Andrew F.; Zevallos, Jose P.; & Winn, Deborah M., et al. (2017). Dietary Fiber Intake and Head and Neck Cancer Risk: A Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium. International Journal of Cancer, 141(9), 1811-1821. PMCID: PMC5797849

Abstract

The possible role of dietary fiber in the etiology of head and neck cancers (HNCs) is unclear. We used individual-level pooled data from 10 case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40-0.59; p for trend <0.001) and with laryngeal cancer (OR = 0.66, 95% CI: 0.54-0.82, p for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral and pharyngeal cancer combined. Nonetheless, inverse associations were consistently observed for the subsites of oral and pharyngeal cancers and within most strata of the considered covariates, for both cancer sites. Our findings from a multicenter large-scale pooled analysis suggest that, although in the presence of between-study heterogeneity, a greater intake of fiber may lower HNC risk. This article is protected by copyright. All rights reserved.

URL

http://dx.doi.org/10.1002/ijc.30886

Reference Type

Journal Article

Year Published

2017

Journal Title

International Journal of Cancer

Author(s)

Kawakita, Daisuke
Lee, Yuan-Chin Amy
Turati, Federica
Parpinel, Maria
Decarli, Adriano
Serraino, Diego
Matsuo, Keitaro
Olshan, Andrew F.
Zevallos, Jose P.
Winn, Deborah M.
Moysich, Kirsten
Zhang, Zuo-Feng
Morgenstern, Hal
Levi, Fabio
Kelsey, Karl T.
McClean, Michael D.
Bosetti, Cristina
Garavello, Werner
Schantz, Stimson
Yu, Guo-Pei
Boffetta, Paolo
Chuang, Shu-Chun
Hashibe, Mia
Ferraroni, Monica
La Vecchia, Carlo
Edefonti, Valeria

PMCID

PMC5797849

ORCiD

Olshan - 0000-0001-9115-5128