Genome-Wide Physical Activity Interactions in Adiposity – A Meta-Analysis of 200,452 Adults

Download as .RIS

Citation

Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda P.; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; & Hadley, David, et al. (2017). Genome-Wide Physical Activity Interactions in Adiposity - A Meta-Analysis of 200,452 Adults. PLOS Genetics, 13(4), e1006528. PMCID: PMC5407576

Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

URL

http://dx.doi.org/10.1371/journal.pgen.1006528

Reference Type

Journal Article

Year Published

2017

Journal Title

PLOS Genetics

Series Title

M Graff et al. PLoS Genet 13 (8), e1006972. 2017. PMID 28832619.

Author(s)

Graff, Mariaelisa
Scott, Robert A.
Justice, Anne E.
Young, Kristin L.
Feitosa, Mary F.
Barata, Llilda P.
Winkler, Thomas W.
Chu, Audrey Y.
Mahajan, Anubha
Hadley, David
Xue, Luting
Workalemahu, Tsegaselassie
Heard-Costa, Nancy L.
den Hoed, Marcel
Ahluwalia, Tarunveer S.
Qi, Qibin
Ngwa, Julius S.
Renström, Frida
Quaye, Lydia
Eicher, John D.
Hayes, James E.
Cornelis, Marilyn C.
Kutalik, Zoltan
Lim, Elise
Luan, Jian'an
Huffman, Jennifer E.
Zhang, Weihua
Zhao, Wei
Griffin, Paula J.
Haller, Toomas
Ahmad, Shafqat
Marques-Vidal, Pedro
Bien, Stephanie A.
Yengo, Loic
Teumer, Alexander
Smith, Albert V.
Kumari, Meena
Harder, Marie Neergaard
Justesen, Johanne M.
Kleber, Marcus E.
Hollensted, Mette
Lohman, Kurt K.
Rivera, Natalia V.
Whitfield, John B.
Zhao, Jing Hua
Stringham, Heather M.
Lyytikainen, Leo-Pekka
Huppertz, Charlotte
Willemsen, Gonneke
Peyrot, Wouter J.
Wu, Ying
Kristiansson, Kati
Demirkan, Ayse
Fornage, Myriam
Hassinen, Maija
Bielak, Lawrence F.
Cadby, Gemma
Tanaka, Toshiko
Magi, Reedik
van der Most, Peter J.
Jackson, Anne U.
Bragg-Gresham, Jennifer L.
Vitart, Veronique
Marten, Jonathan
Navarro, Pau
Bellis, Claire
Pasko, Dorota
Johansson, Asa
Snitker, Soren
Cheng, Yu-Ching
Eriksson, Joel
Lim, Unhee
Aadahl, Mette
Adair, Linda S.
Amin, Najaf
Balkau, Beverley
Auvinen, Juha
Beilby, John
Bergman, Richard N.
Bergmann, Sven
Bertoni, Alain G.
Blangero, John
Bonnefond, Amelie
Bonnycastle, Lori L.
Borja, Judith B.
Brage, Soren
Busonero, Fabio
Buyske, Steven G.
Campbell, Harry
Chines, Peter S.
Collins, Francis S.
Corre, Tanguy
Smith, George Davey
Delgado, Graciela E.
Dueker, Nicole
Dorr, Marcus
Ebeling, Tapani
Eiriksdottir, Gudny
Esko, Tonu
Faul, Jessica D.
Fu, Mao
Faerch, Kristine
Gieger, Christian
Glaser, Sven
Gong, Jian
Gordon-Larsen, Penny
Grallert, Harald
Grammer, Tanja B.
Grarup, Niels
van Grootheest, Gerard
Harald, Kennet
Hastie, Nicholas D.
Havulinna, Aki S.
Hernandez, Dena
Hindorff, Lucia A.
Hocking, Lynne J.
Holmen, Oddgeir L.
Holzapfel, Christina
Hottenga, Jouke-Jan
Huang, Jie
Huang, Tao
Hui, Jennie
Huth, Cornelia
Hutri-Kahonen, Nina
James, Alan L.
Jansson, John-Olov
Jhun, Min A.
Juonala, Markus
Kinnunen, Leena
Koistinen, Heikki A.
Kolcic, Ivana
Komulainen, Pirjo
Kuusisto, Johanna
Kvaloy, Kirsti
Kahonen, Mika
Lakka, Timo A.
Launer, Lenore J.
Lehne, Benjamin
Lindgren, Cecilia M.
Lorentzon, Mattias
Luben, Robert
Marre, Michel
Milaneschi, Yuri
Monda, Keri L.
Montgomery, Grant W.
De Moor, Marleen H. M.
Mulas, Antonella
Muller-Nurasyid, Martina
Musk, Arthur W.
Mannikko, Reija
Mannisto, Satu
Narisu, Narisu
Nauck, Matthias
Nettleton, Jennifer A.
Nolte, Ilja M.
Oldehinkel, Albertine J.
Olden, Matthias
Ong, Ken K.
Padmanabhan, Sandosh
Paternoster, Lavinia
Perez, Jeremiah
Perola, Markus
Peters, Annette
Peters, Ulrike
Peyser, Patricia A.
Prokopenko, Inga
Puolijoki, Hannu
Raitakari, Olli T.
Rankinen, Tuomo
Rasmussen-Torvik, Laura J.
Rawal, Rajesh
Ridker, Paul M.
Rose, Lynda M.
Rudan, Igor
Sarti, Cinzia
Sarzynski, Mark A.
Savonen, Kai
Scott, William R.
Sanna, Serena
Shuldiner, Alan R.
Sidney, Steve
Silbernagel, Gunther
Smith, Blair H.
Smith, Jennifer A.
Snieder, Harold
Stancakova, Alena
Sternfeld, Barbara
Swift, Amy J.
Tammelin, Tuija
Tan, Sian-Tsung
Thorand, Barbara
Thuillier, Dorothee
Vandenput, Liesbeth
Vestergaard, Henrik
van Vliet-Ostaptchouk, Jana V.
Vohl, Marie-Claude
Volker, Uwe
Waeber, Gerard
Walker, Mark
Wild, Sarah H.
Wong, Andrew
Wright, Alan F.
Zillikens, M. Carola
Zubair, Niha
Haiman, Christopher A.
Le Marchand, Loic
Gyllensten, Ulf
Ohlsson, Claes
Hofman, Albert
Rivadeneira, Fernando
Uitterlinden, Andre G.
Perusse, Louis
Wilson, James F.
Hayward, Caroline
Polasek, Ozren
Cucca, Francesco
Hveem, Kristian
Hartman, Catharina A.
Tonjes, Anke
Bandinelli, Stefania
Palmer, Lyle J.
Kardia, Sharon L. R.
Rauramaa, Rainer
Sorensen, Thorkild I. A.
Tuomilehto, Jaakko
Salomaa, Veikko
Penninx, Brenda W. J. H. W.
de Geus, Eco J. C.
Boomsma, Dorret I.
Lehtimaki, Terho
Mangino, Massimo
Laakso, Markku
Bouchard, Claude
Martin, Nicholas G.
Kuh, Diana
Liu, Yongmei
Linneberg, Allan
Marz, Winfried
Strauch, Konstantin
Kivimaki, Mika
Harris, Tamara B.
Gudnason, Vilmundur G.
Volzke, Henry
Qi, Lu
Jarvelin, Marjo-Riitta
Chambers, John C.
Kooner, Jaspal Singh S.
Froguel, Philippe
Kooperberg, Charles L.
Vollenweider, Peter
Hallmans, Goran
Hansen, Torben
Pedersen, Oluf
Metspalu, Andres
Wareham, Nicholas J.
Langenberg, Claudia
Weir, David R.
Porteous, David J.
Boerwinkle, Eric A.
Chasman, Daniel I.
Abecasis, Gonçalo R.
Barroso, Ines
McCarthy, Mark I.
Frayling, Timothy M.
O'Connell, Jeffrey R.
van Duijn, Cornelia M.
Boehnke, Michael
Heid, Iris M.
Mohlke, Karen L.
Strachan, David P.
Fox, Caroline S.
Liu, Ching-Ti
Hirschhorn, Joel N.
Klein, Robert J.
Johnson, Andrew D.
Borecki, Ingrid B.
Franks, Paul W.
North, Kari E.
Cupples, L. Adrienne
Loos, Ruth J. F.
Kilpelainen, Tuomas O.

PMCID

PMC5407576

ORCiD

Gordon-Larsen - 0000-0001-5322-4188
Adair - 0000-0002-3670-8073
Graff - 0000-0001-6380-1735