Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study

Citation

Lange, Leslie A.; Graff, Mariaelisa; Lange, Ethan M.; Young, Kristin L.; Richardson, Andrea S.; Mohlke, Karen L.; North, Kari E.; Harris, Kathleen Mullan; & Gordon-Larsen, Penny (2016). Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study. Annals of Human Genetics, 80(5), 294-305. PMCID: PMC5453181

Abstract

Glycated hemoglobin (HbA1c) is used to classify glycaemia and type 2 diabetes (T2D). Body mass index (BMI) is a predictor of HbA1c levels and T2D. We tested 43 established BMI and obesity loci for association with HbA1c in a nationally representative multiethnic sample of young adults from the National Longitudinal Study of Adolescent to Adult Health [Add Health: age 24-34 years; n = 5641 European Americans (EA); 1740 African Americans (AA); 1444 Hispanic Americans (HA)] without T2D, using two levels of covariate adjustment (Model 1: age, sex, smoking, and geographic region; Model 2: Model 1 covariates plus BMI). Bonferroni adjustment was made for 43 SNPs and we considered P < 0.0011 statistically significant. Means (SD) for HbA1c were 5.4% (0.3) in EA, 5.7% (0.4) in AA, and 5.5% (0.3) in HA. We observed significant evidence for association with HbA1c for two variants near

URL

http://dx.doi.org/10.1111/ahg.12165

Reference Type

Journal Article

Year Published

2016

Journal Title

Annals of Human Genetics

Author(s)

Lange, Leslie A.
Graff, Mariaelisa
Lange, Ethan M.
Young, Kristin L.
Richardson, Andrea S.
Mohlke, Karen L.
North, Kari E.
Harris, Kathleen Mullan
Gordon-Larsen, Penny

PMCID

PMC5453181

ORCiD

Gordon-Larsen - 0000-0001-5322-4188